Peer-reviewed veterinary case report
High manganese levels linked to brain babesiosis in dogs
By Teodorowski, Oliwier et al.·Published in Acta veterinaria Hungarica·2020·1Teodorowscy' Veterinary Clinic·View original on PubMed →
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Original publication title: Elevated serum manganese concentration in dogs as a possible predisposing factor of cerebral babesiosis in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with cerebral babesiosis (a serious infection affecting the brain) showed higher levels of manganese in their blood compared to healthy dogs and those with early babesiosis. This suggests that elevated manganese might play a role in the development of brain issues in dogs suffering from this disease. While the study highlights a potential link, more research is needed to fully understand how manganese affects dogs with cerebral babesiosis. If your dog shows signs of infection or neurological symptoms, it's important to consult your veterinarian for appropriate testing and treatment.
People also search for: dog brain infection symptoms · manganese levels in dogs · treatment for babesiosis in dogs
Abstract
The aim of this study was to demonstrate a relationship between the occurrence of clinical signs of brain involvement in dogs with babesiosis and the concentration of manganese (Mn) in their serum. The study included seven dogs with early babesiosis (Group 1), seven dogs with cerebral babesiosis (Group 2) and seven healthy dogs (Group 3). Haematological and biochemical blood tests were performed in all dogs, and the results were analysed statistically. The Mann-Whitney rank test was used to demonstrate the differences in Mn concentrations, as well as other haematological and biochemical parameters between groups. In dogs in Group 2 with cerebral babesiosis, as compared to dogs in Groups 1 and 3, a statistically significant increase in serum Mn concentration was shown (P = 0.002 and P = 0.029) that may have been associated with the development of anaemia and/or impairment of liver function. Given the well-established neurotoxic effects of Mn in humans, experimental rodents and primates, additional studies on the role of Mn in the pathogenesis of the cerebral form of canine babesiosis are warranted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33372913/