Peer-reviewed veterinary case report
High ATP levels in knee joint fluid of dogs with arthritis
By Torres, Bryan T et al.·Published in Veterinary and comparative orthopaedics and traumatology : V.C.O.T·2016·University of Missouri, United States·View original on PubMed →
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Original publication title: Elevated synovial fluid concentration of adenosine triphosphate in dogs with osteoarthritis or sodium urate-induced synovitis of the stifle.
- Species:
- dog
Plain-English summary
A group of dogs with knee pain from osteoarthritis or inflammation caused by urate crystals had higher levels of a substance called adenosine triphosphate (ATP) in their joint fluid compared to healthy dogs. This finding suggests that ATP might play a role in the pain experienced by these dogs. Understanding this connection could help veterinarians develop better treatments for dogs suffering from joint issues.
People also search for: dog knee pain treatment · osteoarthritis in dogs · elevated ATP in dog joints
Abstract
Adenosine triphosphate has been shown to stimulate nociceptive nerve terminals in joints. Elevated synovial fluid adenosine triphosphate concentrations as well as a correlation between synovial fluid adenosine triphosphate concentrations and osteoarthritic knee pain has been demonstrated in humans, but not yet in dogs. This study documented elevated synovial fluid adenosine triphosphate concentrations in the stifles of dogs with secondary osteoarthritis and urate-induced synovitis, as compared to normal stifles.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27432274/