Peer-reviewed veterinary case report
High levels of inflammation proteins in dog knee arthritis fluid
By Kleine, Stephanie A et al.·Published in Veterinary and comparative orthopaedics and traumatology : V.C.O.T·2020·Department of Small Animal Medicine and Surgery, United States·View original on PubMed →
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Original publication title: Elevated Synovial Fluid Concentration of Monocyte Chemoattractant Protein-1 and Interleukin-8 in Dogs with Osteoarthritis of the Stifle.
- Species:
- dog
Plain-English summary
A group of dogs with osteoarthritis in their knee joints (stifle) showed higher levels of certain proteins in their joint fluid that are linked to inflammation and pain. These proteins, called MCP-1 and IL-8, were found in greater amounts compared to healthy dogs. However, the study did not find a direct link between the levels of these proteins and how much pain or mobility issues the dogs experienced, as reported by their owners. This suggests that while these proteins are present in dogs with osteoarthritis, they may not be reliable indicators of pain or severity of the condition.
People also search for: dog knee pain treatment · osteoarthritis in dogs symptoms · elevated MCP-1 IL-8 in dogs
Abstract
Chemokines such as monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) have been shown to cause monocyte and natural killer cell chemotaxis and polymorphonuclear cell chemotaxis, respectively. Additionally, MCP-1 signalling has been implicated in modulating pain. Elevated synovial fluid concentrations of MCP-1 and IL-8 have been demonstrated in humans with osteoarthritis, but currently there are no studies evaluating synovial MCP-1 or IL-8 concentrations in dogs. Additionally, there are no canine studies evaluating the correlation between these chemokines and caregiver perceived pain and mobility, as measured by the clinical metrology instrument, Liverpool Osteoarthritis in Dogs. This study documented elevated synovial fluid concentrations of IL-8 and MCP-1 in the stifle of dogs with secondary osteoarthritis compared with normal stifles. However, this study found no correlation between MCP-1 or IL-8 and Liverpool Osteoarthritis in Dogs or radiographic severity of osteoarthritis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31756750/