Peer-reviewed veterinary case report
Elevation of circulating LOX-1 ligand levels in Zucker obese and diabetic rats.
- Journal:
- Obesity research & clinical practice
- Year:
- 2015
- Authors:
- Wakabayashi, Ichiro et al.
- Affiliation:
- Department of Environmental and Preventive Medicine · Japan
- Species:
- rodent
Abstract
LOX-1 ligands containing apolipoprotein B (LAB) reflect ligand activity of LOX-1, which is a key molecule for initiation of atherosclerosis. The Zucker rat is a well-known model used for research on obesity and diabetes. Blood levels of LAB were compared among Zucker fatty (ZF), Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats. Log-transformed LAB was significantly higher in ZF and ZDF rats than in control ZL rats, while no significant difference was found in log-transformed LAB of ZF and ZDF rats. This study for the first time demonstrated that circulating LOX-1 ligands were elevated in obesity and diabetes model rats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25434992/