Peer-reviewed veterinary case report
Eltrombopag treatment for a dog with aplastic pancytopenia
By Kelly, Darren et al.·Published in Journal of veterinary internal medicine·2020·Southern Counties Veterinary Specialists, United Kingdom·View original on PubMed →
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Original publication title: Eltrombopag treatment of a dog with idiopathic aplastic pancytopenia.
- Species:
- dog
Plain-English summary
A 5-year-old mixed-breed dog was diagnosed with idiopathic aplastic pancytopenia, a serious condition that causes low blood cell counts and can be life-threatening. Initially, the dog was treated with prednisolone and cyclosporine, but there was no improvement. After adding eltrombopag, a medication that helps increase blood cell production, the dog achieved complete remission and continued to do well even after stopping the medication. This case suggests that eltrombopag can be an effective treatment option for dogs with this condition.
People also search for: dog low blood cell count treatment · idiopathic aplastic pancytopenia in dogs · eltrombopag for dogs
Abstract
Idiopathic aplastic pancytopenia is an uncommon disease in dogs which results in pancytopenia and for which an immune-mediated etiology is suspected. A small number of affected dogs reported in the veterinary literature have responded to immunosuppressive medication but the prognosis generally is considered poor with a reported mortality rate of 80%. Reported response rates to immunosuppression alone in affected people are low with overall and complete responses of 65 and 10%, respectively. With the addition of eltrombopag, an orally available thrombopoietin receptor agonist, reported overall and complete response rates in people increase to 94 and 58%, respectively. Herein, we report the use of eltrombopag in a dog with idiopathic aplastic pancytopenia. Eltrombopag was started after no response was seen to treatment with prednisolone and cyclosporine. Complete remission was achieved after the addition of eltrombopag and was sustained after stopping the medication.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32096575/