Peer-reviewed veterinary case report
Emphasis on cell turnover in two hosts infected by bovine leukemia virus: a rationale for host susceptibility to disease.
- Journal:
- Veterinary immunology and immunopathology
- Year:
- 2008
- Authors:
- Florins, Arnaud et al.
- Affiliation:
- Gembloux Agricultural University
Abstract
Bovine leukemia virus (BLV) is a deltaretrovirus that infects and induces accumulation of B-lymphocytes in the peripheral blood and lymphoid tissues of cattle, leading to leukemia/lymphoma. BLV can also be experimentally transmitted to sheep, in which disease appears earlier and at higher frequencies. Abnormal accumulation of leukemic B-lymphocytes results from an alteration of different parameters that include cell proliferation and death as well as migration to lymphoid tissues. Interestingly, B lymphocyte turnover is increased in BLV-infected sheep but reduced in cattle, revealing a potential relationship between cell kinetics and disease progression.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18513803/