Peer-reviewed veterinary case report
Endocrinopathic Laminitis.
- Journal:
- The Veterinary clinics of North America. Equine practice
- Year:
- 2021
- Authors:
- Grenager, Nora S
- Affiliation:
- Steinbeck Peninsula Equine Clinics · United States
- Species:
- horse
Plain-English summary
Endocrinopathic laminitis is a serious hoof condition that mainly happens due to problems with insulin, a hormone that helps control blood sugar. This condition can lead to changes in the hoof structure, causing pain and difficulty for the horse. It's important for horse owners to understand how to reduce the risk of this condition, especially by having older horses checked for specific hormone issues and younger horses monitored for insulin problems. Regular hoof evaluations can help catch issues early and prevent this painful condition from developing. Overall, with proper care and monitoring, many cases of endocrinopathic laminitis can be avoided.
Abstract
Endocrinopathic laminitis (EL) primarily occurs because of insulin dysregulation (ID) mediated through downstream effects of insulin on IGF-1R in lamellar tissues. There is likely contributing vascular and metabolic dysfunction within the lamellae, but EL is relatively non-inflammatory. EL is associated with lamellar stretching, proliferation, and failure, ultimately causing failure of the suspensory apparatus of the distal phalanx. Proper education regarding mitigating risk factors makes this a largely preventable cause of laminitis. Annual hoof evaluation plus screening geriatric horses for pituitary pars intermedia dysfunction and ID, and younger horses for ID, can significantly decrease the incidence of this devastating condition.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/34674908/