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Peer-reviewed veterinary case report

Endogenous neurosteroid synthesis modulates seizure frequency.

Journal:
Annals of neurology
Year:
2010
Authors:
Lawrence, Courtney et al.
Affiliation:
Department of Neurology · United States

Abstract

Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by gamma-aminobutyric acid receptors and have anticonvulsant action.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/20437568/