Peer-reviewed veterinary case report
Endothelium-derived ET-1 and the development of renal injury.
- Journal:
- American journal of physiology. Regulatory, integrative and comparative physiology
- Year:
- 2015
- Authors:
- De Miguel, Carmen et al.
- Affiliation:
- Department of Medicine
Abstract
The role of the vasoactive peptide endothelin-1 (ET-1) in renal injury is not fully understood. In this review, we examine the genetic models available to understand the autocrine/paracrine mechanisms by which ET-1 leads to renal injury and propose the working hypothesis that endothelium-derived ET-1 induces renal injury by initiating renal tubular apoptosis in a paracrine manner.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25994955/