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Peer-reviewed veterinary case report

Engineered bacteria recycle tumor metabolic waste to boost immunotherapy.

Journal:
Cell host & microbe
Year:
2021
Authors:
Cubillos-Ruiz, Juan R & Cubillos-Ruiz, Andres
Affiliation:
Department of Obstetrics and Gynecology · United States

Abstract

A recent study published in Nature by Canale et al. (2021) shows that engineered probiotic bacteria can be used to augment the availability of nutrients required for optimal immune cell function in tumors. This approach enhances anti-tumor immunity and improves the efficacy of immunotherapy in mouse models of cancer.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/34883059/