Peer-reviewed veterinary case report
Engineering a potent boron-10-enriched polymeric nanoparticle for boron neutron capture therapy.
- Journal:
- Nanomedicine (London, England)
- Year:
- 2023
- Authors:
- Chan, Wei-Jen et al.
- Affiliation:
- Department of Pharmaceutical Sciences · United States
- Species:
- rodent
Abstract
Boron neutron capture therapy (BNCT) is a promising cancer treatment that eliminates tumor cells by triggering high-energy radiation within cancer cells.evaluation of poly(vinyl alcohol)/boric acid crosslinked nanoparticles (PVA/BA NPs) for BNCT.PVA/BA NPs were synthesized and intravenously injected into tumor-bearing mice for BNCT.Theboron uptake of PVA/BA NPs in tumor cells was 70-fold higher than the required boron uptake for successful BNCT. In anstudy, PVA/BA NPs showed a 44.29% reduction in tumor size compared with clinically used boronophenylalanine for oral cancer in a murine model.PVA/BA NPs exhibited effective therapeutic results for oral cancer treatments in BNCT.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37306216/