Peer-reviewed veterinary case report
Enhanced acyclovir delivery using w/o type microemulsion: preclinical assessment of antiviral activity using murine model of zosteriform cutaneous HSV-1 infection.
- Journal:
- Artificial cells, nanomedicine, and biotechnology
- Year:
- 2018
- Authors:
- Kaur, Amanpreet et al.
- Affiliation:
- University Institute of Pharmaceutical Sciences · India
- Species:
- rodent
Abstract
The present study was aimed to develop and evaluate a microemulsion-based dermal drug delivery of an antiviral agent, acyclovir. A water-in-oil microemulsion was prepared using isopropyl myristate, Tween 20, Span 20, water and dimethylsulphoxide. It was characterized for drug content, stability, globule size, pH, viscosity and ex vivo permeation through mice skin. In vivo antiviral efficacy of optimized formulation was assessed in female Balb/c mice against herpes simplex virus-I (HSV-I)-induced infection. It was observed that optimized formulation when applied 24-h post-infection could completely inhibit the development of cutaneous herpetic lesions vis-à-vis marketed cream.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28403666/