Peer-reviewed veterinary case report
Improved gum healing in dogs with furcation defects using progranulin
By Liu, Wenchuan et al.·Published in Journal of clinical periodontology·2024·Department of Periodontology, China·View original on PubMed →
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Original publication title: Enhanced immunomodulation and periodontal regeneration efficacy of subgingivally delivered progranulin-loaded hydrogel as an adjunct to non-surgical treatment for Class II furcation involvement in dogs.
- Species:
- dog
Plain-English summary
A dog with periodontal disease and Class II furcation involvement (a type of gum disease affecting the roots of teeth) was treated with a new gel containing progranulin, alongside standard dental cleaning. After eight weeks, the dogs that received the gel showed significant improvement in gum health compared to those that only had the cleaning. The treatment not only reduced inflammation but also helped regenerate bone and gum tissue around the affected teeth. This suggests that using the progranulin gel could be a beneficial addition to traditional dental treatments for dogs with gum disease.
People also search for: dog gum disease treatment · periodontal disease in dogs · progranulin for dog dental health
Abstract
AIM: To evaluate the effect of subgingival delivery of progranulin (PGRN)/gelatin methacryloyl (GelMA) complex as an adjunct to scaling and root planing (SRP) on an experimental periodontitis dog model with Class II furcation involvement (FI). MATERIALS AND METHODS: A Class II FI model was established, and the defects were divided into four treatment groups: (a) no treatment (control); (b) SRP; (c) SRP + GelMA; (d) SRP + PGRN/GelMA. Eight weeks after treatment, periodontal parameters were recorded, gingival crevicular fluid and gingival tissue were collected for ELISA and RT-qPCR, respectively, and mandibular tissue blocks were collected for micro computed tomography (micro-CT) scanning and hematoxylin and eosin (H&E) staining. RESULTS: The SRP + PGRN/GelMA group showed significant improvement in all periodontal parameters compared with those in the other groups. The expression of markers related to M1 macrophage and Th17 cell significantly decreased, and the expression of markers related to M2 macrophage and Treg cell significantly increased in the SRP + PGRN/GelMA group compared with those in the other groups. The volume, quality and area of new bone and the length of new cementum in the root furcation defects of the PGRN/GelMA group were significantly increased compared to those in the other groups. CONCLUSIONS: Subgingival delivery of the PGRN/GelMA complex could be a promising non-surgical adjunctive therapy for anti-inflammation, immunomodulation and periodontal regeneration.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38462847/