Peer-reviewed veterinary case report
Enhancement of leukocyte adhesion after percutaneous irradiation in rats with hepatocellular carcinoma.
- Journal:
- World journal of gastroenterology
- Year:
- 2005
- Authors:
- Maksan, Sasa-Marcel et al.
- Affiliation:
- Department of Surgery · Germany
- Species:
- rodent
Abstract
AIM: To evaluate the effects of percutaneous radiation on leukocyte-endothelium interaction (LEI) in experimental hepatocellular carcinoma (HCC). METHODS: Twelve ACI rats underwent HCC-inoculation, six of which on day 12 received low-dose external radiation and six did not. After 12 h intravital microscopy was performed. RESULTS: LEI was significantly reduced in tumor tissue. However, irradiation of liver sinusoids and tumor tissue with 6 Gy led to a significant activation of leukocyte adhesion in the tumor with a marked increase of the proinflammatory cytokine TNF-alpha. CONCLUSION: The findings indicate that the immunological tumor-endothelial barrier can be overcome by external irradiation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15800992/