Peer-reviewed veterinary case report
Improved repair of dog alveolar cleft using stem cells
By Yuanzheng, Chen et al.·Published in Plastic and reconstructive surgery·2015·Linyi People's Hospital, China·View original on PubMed →
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Original publication title: Enhancement of the repair of dog alveolar cleft by an autologous iliac bone, bone marrow-derived mesenchymal stem cell, and platelet-rich fibrin mixture.
- Species:
- dog
Plain-English summary
A group of 20 beagle dogs with a surgical condition called unilateral alveolar cleft (a gap in the upper jaw) received different treatments to help repair the area. One group was treated with a mixture of their own bone, stem cells from bone marrow, and platelet-rich fibrin, while others received variations of these treatments. The dogs that received the mixture showed the best results, with more new bone growth and better integration with the jawbone compared to those that only had the standard bone graft. This suggests that using both stem cells and platelet-rich fibrin together can significantly improve healing in dogs with this condition.
People also search for: dog alveolar cleft treatment · beagle jaw surgery recovery · stem cell therapy for dogs
Abstract
BACKGROUND: Autologous bone graft has been regarded as the criterion standard for the repair of alveolar cleft. However, the most prominent issue in alveolar cleft treatment is the high absorption rate of the bone graft. The authors' objective was to investigate the effects of an autologous iliac bone, bone marrow-derived mesenchymal stem cell, and platelet-rich fibrin mixture on the repair of dog alveolar cleft. METHODS: Twenty beagle dogs with unilateral alveolar clefts created by surgery were divided randomly into four groups: group A underwent repair with an autologous iliac bone, bone marrow-derived mesenchymal stem cell, and platelet-rich fibrin mixture; group B underwent repair with autologous iliac bone and bone marrow-derived mesenchymal stem cells; group C underwent repair with autologous iliac bone and platelet-rich fibrin; and group D underwent repair with autologous iliac bone as the control. One day and 6 months after transplantation, the transplant volumes and bone mineral density were assessed by quantitative computed tomography. All of the transplants were harvested for hematoxylin and eosin staining 6 months later. RESULTS: Bone marrow-derived mesenchymal stem cells and platelet-rich fibrin transplants formed the greatest amounts of new bone among the four groups. The new bone formed an extensive union with the underlying maxilla in groups A, B, and C. Transplants with the bone marrow-derived mesenchymal stem cells, platelet-rich fibrin, and their mixture retained the majority of their initial volume, whereas the transplants in the control group showed the highest absorption rate. Bone mineral density of transplants with the bone marrow-derived mesenchymal stem cells, platelet-rich fibrin, and their mixture 6 months later was significantly higher than in the control group (p < 0.05), and was the highest in bone marrow-derived mesenchymal stem cells and platelet-rich fibrin mixed transplants. Hematoxylin and eosin staining showed that the structure of new bones formed the best in group A. CONCLUSION: Both bone marrow-derived mesenchymal stem cells and platelet-rich fibrin are capable of improving the repair of dog alveolar cleft, and the mixture of them is more potent than each one of them used singly for enhancing new bone regeneration.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25835246/