Peer-reviewed veterinary case report
Environment makes amphetamine-induced dopamine release in the nucleus accumbens totally impulse-dependent.
- Journal:
- Synapse (New York, N.Y.)
- Year:
- 2005
- Authors:
- Ventura, Rossella & Puglisi-Allegra, Stefano
- Affiliation:
- Dipartimento di Psicologia · Italy
- Species:
- rodent
Abstract
Environmental condition such as food restriction has been shown to produce sensitization to the stimulant and rewarding effects of amphetamine in the low responsive DBA/2J genotype. Here, we report that food-restricted DBA/2J mice lose the impulse-independent component of psychostimulant-induced dopamine release in the nucleus accumbens that is replaced totally by impulse-dependent dopamine release. These results indicate for the first time that the crucial effect of environment-induced sensitization is a dramatic increase of the impulse dependent component.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16138319/