Peer-reviewed veterinary case report
Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction.
- Journal:
- Advanced materials (Deerfield Beach, Fla.)
- Year:
- 2015
- Authors:
- Nguyen, Mary M et al.
- Affiliation:
- Department of Bioengineering · United States
- Species:
- rodent
Abstract
A method for targeting to and retaining intravenously injected nanoparticles at the site of acute myocardial infarction in a rat model is described. Enzyme-responsive peptide-polymer amphiphiles are assembled as spherical micellar nanoparticles, and undergo a morphological transition from spherical-shaped, discrete materials to network-like assemblies when acted upon by matrix metalloproteinases (MMP-2 and MMP-9), which are up-regulated in heart tissue post-myocardial infarction.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26305446/