Peer-reviewed veterinary case report
Enzymes making inflammatory chemicals in skin of dogs with atopic
By Schlotter, Yvette M et al.·Published in Experimental dermatology·2010·View original on PubMed →
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Original publication title: Enzymes involved in the conversion of arachidonic acid to eicosanoids in the skin of atopic dogs.
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a chronic skin condition causing itching and inflammation) showed higher levels of certain enzymes in their skin compared to healthy dogs. These enzymes are involved in producing inflammatory substances that can worsen their skin problems. Understanding these enzymes could help veterinarians develop better treatments to relieve the symptoms of atopic dermatitis in dogs. Targeting these enzymes may lead to improved skin health and comfort for affected dogs.
People also search for: dog itching treatment · atopic dermatitis in dogs · skin problems in dogs · dog skin inflammation relief
Abstract
Canine atopic dermatitis (AD), a chronic inflammatory skin disease, shares characteristics with its human counterpart. To get insight into the role of enzymes involved in production of prostaglandin E(2) (PGE2) and leukotriene B(4) (LTB(4)), potent inflammatory mediators originating from membrane-derived arachidonic acid (AA), expression of genes encoding these enzymes and receptors was quantified by qPCR in non-lesional and lesional skin from atopic dogs and in healthy skin. Significantly higher mRNA expression of the key enzymes 5-lipoxygenase (5-LO), 5-LO activating protein (FLAP), leukotriene A(4) hydrolase (LTA(4)H) and prostaglandin E synthase 1 (mPGES-1) and their receptors (PGE receptors 2 and 3) were observed. Being responsible for elevated levels of metabolites of the 3-series prostaglandins and the 5-series leukotrienes these enzymes may be interesting targets for therapy that should result in amelioration of clinical signs in canine atopic dermatitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20201960/