Peer-reviewed veterinary case report
Helicobacter stomach infection in Japanese dogs with gut disease
By Kubota-Aizawa, Sanae et al.·Published in Veterinary journal (London, England : 1997)·2017·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Epidemiological study of gastric Helicobacter spp. in dogs with gastrointestinal disease in Japan and diversity of Helicobacter heilmannii sensu stricto.
- Species:
- dog
Plain-English summary
A study found that 34.7% of dogs with gastrointestinal issues in Japan were infected with different types of Helicobacter bacteria, which can cause stomach problems. The researchers discovered that dogs infected with a specific strain, Helicobacter heilmannii, were more likely to have moderate to severe gastritis (inflammation of the stomach lining). This suggests that these bacteria could be linked to more serious stomach issues in dogs. Treatment options for gastritis often include medications to reduce stomach acid and antibiotics to clear the infection, which may help improve the dog's condition.
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Abstract
Epidemiological and pathological studies of Helicobacter spp. in canine stomachs in Japan were performed to investigate strain specific pathogenicity. Gastric biopsies from 144 dogs with gastrointestinal diseases were evaluated for the presence of Helicobacter spp. using genus and species specific PCRs for Helicobacter felis, Helicobacter bizzozeronii, Helicobacter heilmannii sensu stricto (s.s.) and Helicobacter pylori. PCR indicated that 50/144 (34.7%) dogs were infected with Helicobacter spp. Of the genus positive samples, 21/50 could not be amplified by any of the species specific PCRs. To investigate Helicobacter at the species level, partial ureAB gene sequences from 48/50 genus positive samples were determined; 47 strains were identified. Thirty-five strains from 45 cases were closely related to H. heilmannii s.s. (89-99% sequence similarity), seven strains from seven cases were closely related to H. bizzozeronii (95-99% sequence similarity), three strains from three cases were closely related to Helicobacter felis (86%, 98% and 99% sequence similarity), one strain from one case was closely related to Helicobacter salomonis (99% sequence similarity) and one strain from one case was closely related to H. pylori (99% sequence similarity). Dogs infected with Helicobacter spp. most similar to H. heilmannii s.s. had a higher frequency of moderate to severe gastritis than dogs negative for Helicobacter spp. (P=0.044). In conclusion, the predominant Helicobacter spp. detected in canine stomachs in our study were most closely related to H. heilmannii s.s. and displayed substantial genetic diversity. Infection with Helicobacter spp. may be associated with more severe gastritis in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28720300/