Peer-reviewed veterinary case report
Epidermal growth factor receptor is high in dog bladder cancer tumors
By Hanazono, Kiwamu et al.·Published in The Journal of veterinary medical science·2015·Department of Small Animal Clinical Sciences, Japan·View original on PubMed →
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Original publication title: Epidermal growth factor receptor expression in canine transitional cell carcinoma.
- Species:
- dog
Plain-English summary
A study found that dogs with transitional cell carcinoma (TCC), a serious bladder tumor, had much higher levels of a protein called epidermal growth factor receptor (EGFR) compared to healthy dogs. This suggests that measuring EGFR levels could help veterinarians diagnose TCC more accurately. The research showed that high EGFR levels were linked to the presence of TCC, making it a potential marker for this type of cancer in dogs. Early diagnosis is crucial since TCC can be life-threatening.
People also search for: dog bladder cancer symptoms · transitional cell carcinoma in dogs · EGFR testing for dog cancer
Abstract
Transitional cell carcinoma (TCC), a urinary bladder tumor with high mortality, is encountered commonly in dogs. Whereas overexpression of epidermal growth factor receptor (EGFR) is associated with development of human urinary bladder cancer, information on EGFR expression in canine TCC is lacking. In this study, EGFR protein and mRNA expression in canine normal bladder (n=5), polypoid cystitis (n=5) and TCC (n=25) were examined by immunohistochemistry and real-time polymerase chain reaction. EGFR protein expression was significantly higher in TCC than that in normal healthy bladder (P<0.001) and polypoid cystitis (P<0.005). High EGFR protein expression was significantly (P<0.01) associated with TCC with a sensitivity of 72% and specificity of 100%. Comparative analysis of protein and mRNA expression levels in TCC showed significant positive correlation (r=0.88, P<0.05) between mRNA and protein expression. These findings suggest that intense expression of EGFR protein could be used as a marker to help canine TCC diagnosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25223345/