Peer-reviewed veterinary case report
Epithelial immunization induces polyfunctional CD8+ T cells and optimal mousepox protection.
- Journal:
- Journal of virology
- Year:
- 2014
- Authors:
- Hersperger, Adam R et al.
- Affiliation:
- Department of Microbiology and Immunology · United States
- Species:
- rodent
Abstract
We assessed several routes of immunization with vaccinia virus (VACV) in protecting mice against ectromelia virus (ECTV). By a wide margin, skin scarification provided the greatest protection. Humoral immunity and resident-memory T cells notwithstanding, several approaches revealed that circulating, memory CD8(+) T cells primed via scarification were functionally superior and conferred enhanced virus control. Immunization via the epithelial route warrants further investigation, as it may also provide enhanced defense against other infectious agents.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24899206/