Peer-reviewed veterinary case report
Epithelial membrane antigen-reactive feline chordoid meningioma in a European wildcat (Felis silvestris).
- Journal:
- Journal of comparative pathology
- Year:
- 2023
- Authors:
- Franzen, Jan et al.
- Affiliation:
- Institute of Animal Pathology
- Species:
- cat
Plain-English summary
A 5.5-year-old European wildcat from a Swiss zoo was found dead after showing signs of neurological problems and a suspected tumor in its right ear canal, along with a long-term ear infection. A thorough examination after death showed a large tumor in the brain that had spread into the ear canal, which was identified as a rare type of meningioma called chordoid meningioma. This type of tumor has mostly been seen in humans and dogs. The cells from the tumor showed certain markers that are typically found in tumors, including a specific marker called epithelial membrane antigen (EMA), which had not been previously reported in cats. Unfortunately, the outcome was not positive, as the wildcat did not survive.
Abstract
Meningioma is the most frequent intracranial neoplasm in cats. Here we describe the first case of chordoid meningioma (CM), a rare grade II meningioma subtype, in a 5.5-year-old European wildcat (Felis silvestris) from a Swiss zoo. The wildcat was found dead after a clinical history of neurological signs and clinical suspicion of a carcinoma in the right external ear canal with concurrent chronic otitis. Post-mortem examination revealed a large intracranial, extra-axial and intradural neoplasm that invaded into the right ear canal and had histological features compatible with CM, which has been only reported in humans and dogs. Neoplastic cells expressed vimentin but were negative for glial fibrillary acidic protein, S100 and pancytokeratin. Immunohistochemistry revealed epithelial membrane antigen (EMA) expression in neoplastic cells. To the best of our knowledge, we provide the first evidence of EMA expression in feline meningioma.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/36791602/