Peer-reviewed veterinary case report
Salivary gland cancer in a 7-year-old Cavalier King Charles spaniel
By Park, C-H et al.·Published in Journal of comparative pathology·2018·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: Epithelial-Myoepithelial Carcinoma in a Canine Salivary Gland.
- Species:
- dog
Plain-English summary
A 7-year-old male Cavalier King Charles Spaniel was brought to the vet with a lump in his neck. After examining the mass, the vet found it was a type of cancer called epithelial-myoepithelial carcinoma, which likely started in the salivary gland. The diagnosis was confirmed through special tests that looked at the cells in the lump. Unfortunately, this type of cancer can be serious, and treatment options would typically involve surgery or other therapies, depending on the specifics of the case.
People also search for: dog neck lump · Cavalier King Charles Spaniel cancer · salivary gland tumor in dogs
Abstract
A 7-year-old male cavalier King Charles spaniel was presented with a cervical subcutaneous mass. The mass had a multilobular growth pattern and each individual lobule contained ductal epithelial cells and myoepithelial cells surrounding the ductal cells. Immunohistochemically, the ductal epithelial cells were positive for cytokeratin (CK) 7 and CAM5.2 and the myoepithelial cells were positive for α-smooth muscle actin and p63. Both types of cells were positive for CK14, a myoepithelial cell marker. Ultrastructurally, the ductal epithelial cells were attached by desmosomes and contained abundant intracytoplasmic tonofilaments. Some ductal epithelial cells contained myofilaments characteristic of myoepithelial cells. Based on these findings, a diagnosis of epithelial-myoepithelial carcinoma was made. It is presumed that the tumour originated from an intercalated duct in a parotid salivary gland.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30502796/