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Peer-reviewed veterinary case report

Equine acquired multiple acyl-CoA dehydrogenase deficiency (MADD) in 14 horses associated with ingestion of Maple leaves (Acer pseudoplatanus) covered with European tar spot (Rhytisma acerinum).

Journal:
Molecular genetics and metabolism
Year:
2010
Authors:
van der Kolk, J H et al.
Affiliation:
Department of Equine Sciences · Netherlands
Species:
horse

Abstract

This case-series describes fourteen horses suspected of equine acquired multiple acyl-CoA dehydrogenase deficiency (MADD) also known as atypical myopathy of which seven cases were confirmed biochemically with all horses having had access to leaves of the Maple tree (Acer pseudoplatanus) covered with European tar spot (Rhytisma acerinum). Assessment of organic acids, glycine conjugates, and acylcarnitines in urine was regarded as gold standard in the biochemical diagnosis of equine acquired multiple acyl-CoA dehydrogenase deficiency.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/20655779/