Peer-reviewed veterinary case report
Equine herpesvirus 1 utilizes a novel herpesvirus entry receptor.
- Journal:
- Journal of virology
- Year:
- 2005
- Authors:
- Frampton, Arthur R et al.
- Affiliation:
- Department of Molecular Genetics and Biochemistry · United States
- Species:
- horse
Abstract
The well-described herpesvirus entry receptors HveA (TNFRSF14), HveB (nectin 2), and HveC (nectin 1) have been shown to mediate the entry of alphaherpesviruses. Our findings showed that the alphaherpesvirus equine herpesvirus 1 (EHV-1) efficiently entered and replicated in CHO-K1 cells that lack the entry receptors HveA, HveB, and HveC, demonstrating that EHV-1 utilizes a unique entry receptor. As with other alphaherpesviruses, efficient EHV-1 entry was dependent on glycoprotein D and cell surface glycosaminoglycans.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15709036/