Peer-reviewed veterinary case report
Horse stem cell injections safely improve osteoarthritis in dogs
By Punzón, Eva et al.·Published in Journal of the American Veterinary Medical Association·2022·1EquiCord SL, Spain·View original on PubMed →
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Original publication title: Equine umbilical cord mesenchymal stem cells demonstrate safety and efficacy in the treatment of canine osteoarthritis: a randomized placebo-controlled trial.
- Species:
- dog
Plain-English summary
Eighty dogs with hip or elbow osteoarthritis received an injection of mesenchymal stem cells (MSCs) from horse umbilical cords to see if it would help their joint pain. After eight weeks, many dogs showed improvement in their ability to walk and their overall quality of life, with 63% showing better gait and 77% improving in orthopedic exams. Most owners felt their pets were doing better, and follow-ups revealed that many dogs continued to benefit from the treatment for over six months without any serious side effects. This suggests that MSC injections could be a safe and effective option for dogs suffering from osteoarthritis.
People also search for: dog osteoarthritis treatment · stem cell therapy for dogs · improving dog joint pain · canine hip pain relief · dog elbow arthritis injection
Abstract
OBJECTIVE: To demonstrate the efficacy and safety of mesenchymal stem cells (MSCs) for xenogeneic use with intra-articular administration in dogs with osteoarthritis. ANIMALS: 80 client-owned dogs with naturally occurring osteoarthritis in elbow or hip. PROCEDURES: A multicentric, double-blinded, parallel, randomized and placebo-controlled clinical trial was performed. After intra-articular injection of equine umbilical cord MSCs, dogs were reexamined at weeks 4, 8, and 12 using a force platform (gait analysis), orthopedic assessment, and validated owner questionnaire. Eighteen months after treatment, a long-term follow-up was done. RESULTS: Best results were obtained 8 weeks after treatment, where 63% of the patients showed an improvement in the gait analysis. Also 8 weeks after treatment, 77% of the dogs improved in the orthopedic examination; 65% of the owners considered that the treatment improved their pet's quality of life 8 weeks after treatment. The long-term follow-up revealed that 59% of the owners observed a duration of effect longer than 6 months after a single intra-articular injection of equine umbilical cord MSCs. No systemic or permanent adverse events were detected at any time point. CLINICAL RELEVANCE: Results of this study demonstrated the safety and efficacy of intra-articular administration of xenogeneic MSCs for the treatment of canine osteoarthritis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36198051/