Peer-reviewed veterinary case report
Anatolian shepherd dog with erosive rhinitis like Wegener's
By Böhm, Marlies & Basson, Sandra·Published in Journal of the South African Veterinary Association·2015·King Edward Veterinary Referral Hospital·View original on PubMed →
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Original publication title: Erosive rhinitis resembling granulomatosis with polyangiitis (Wegener's granulomatosis) in an Anatolian shepherd dog.
- Species:
- dog
Plain-English summary
A young Anatolian shepherd was brought to the vet with severe nasal discharge, fever, lethargy, and stiffness. Tests revealed that the dog had a rare condition resembling a human disease called granulomatosis with polyangiitis, which involves inflammation of blood vessels. The vet treated the dog with immunosuppressive doses of prednisone, and the symptoms improved quickly and completely, with no signs of recurrence. This case highlights a unique presentation of nasal issues in dogs and the effectiveness of prednisone for treatment.
People also search for: dog nasal discharge treatment · Anatolian shepherd fever · prednisone for dog rhinitis
Abstract
Granulomatosis with polyangiitis (Wegener's granulomatosis) is one of the idiopathicimmune-mediated small-vessel vasculitides described in humans which are characterised by the presence of circulating antineutrophil cytoplasmic antibodies. It most commonly involves capillaries, venules and arterioles of the ear, nose and throat, lungs and glomeruli. A case of destructive haemopurulent rhinitis associated with relapsing periods of pyrexia, lethargy and stiffness as well as generalised pulmonary infiltrates in a young Anatolian shepherd dog is presented that closely resembles granulomatosis with polyangiitis (GPA) as reported in humans. Perinuclear antineutrophil cytoplasmic antibodies (pANCA) were detected in the dog's serum. Signs resolved promptly and completely once immunosuppressive doses of prednisone were administered, and have not recurred. This is the first report onthe use of pANCA to investigate rhinitis in dogs. It is also, to the authors' knowledge, the first description of a relapsing haemopurulent lytic rhinitis in this species. The concurrent manifestations of erosive haemopurulent rhinitis, ground-glass opacities on pulmonary computed tomography, pyrexia and listlessness resemble GPA as described in humans.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26018737/