Peer-reviewed veterinary case report
Dog develops severe skin reaction and clotting disorder after insect
By Rosenbaum, M R & Kerlin, R L·Published in Journal of the American Veterinary Medical Association·1995·Department of Clinical Studies, United States·View original on PubMed →
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Original publication title: Erythema multiforme major and disseminated intravascular coagulation in a dog following application of a d-limonene-based insecticidal dip.
- Species:
- dog
Plain-English summary
A dog developed severe lethargy and weakness, along with painful mouth sores and skin lesions, just 24 hours after being treated with a d-limonene-based insecticidal dip. Blood tests showed serious issues, including low platelet counts and signs of internal bleeding. Despite receiving intensive care, the dog suffered from severe bleeding in the chest and abdomen and unfortunately passed away. A necropsy revealed extensive skin damage and internal hemorrhaging. This case highlights the potential dangers of using certain insecticidal dips on pets.
People also search for: dog skin lesions after insecticide · dog lethargy and weakness · d-limonene toxicity in dogs · dog bleeding after treatment · insecticidal dip side effects in dogs
Abstract
Erythema multiforme major and disseminated intravascular coagulation developed in a dog 24 hours after exposure to a d-limonene-based insecticidal dip. Clinical signs included severe lethargy and weakness, ulceration of the oral mucosa, and erythematous serpiginous, annular, and arciform lesions on the head, trunk, and limbs. Clinicopathologic abnormalities included leukocytosis with neutrophilia, normocytic normochromic anemia, thrombocytopenia, prolongation of prothrombin and partial thromboplastin times, increased fibrin degradation products, hypoproteinemia, hyponatremia, hypochloremia, azotemia, high serum alanine aminotransferase and alkaline phosphatase activities, and high serum bilirubin concentration. Despite intensive supportive care, the dog developed severe intrathoracic and abdominal hemorrhage and died. Necropsy revealed severe diffuse epidermal necrosis and widespread hemorrhage within organs. Insecticidal dips containing d-limonene have the potential to induce various toxic effects, including, possibly, erythema multiforme major, and should be used cautiously.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/7591926/