Peer-reviewed veterinary case report
Erythritol sugar stops growth of dog skin infection bacteria
By Onishi-Sakamoto, Saki et al.·Published in Frontiers in veterinary science·2023·Graduate School of Agriculture, Japan·View original on PubMed →
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Original publication title: Erythritol alters phosphotransferase gene expression and inhibits thegrowth ofisolated from canines with pyoderma.
- Species:
- dog
Plain-English summary
A study found that erythritol, a type of sugar alcohol, can help fight skin infections in dogs with pyoderma, a condition that causes skin lesions. Researchers tested erythritol on various strains of Staphylococcus bacteria isolated from dogs suffering from this skin issue and discovered it inhibited the bacteria's growth. This means that erythritol could potentially be used as a treatment option for dogs with pyoderma, especially since the bacteria's growth returned when glucose was added back. This suggests that erythritol may work by starving the bacteria of sugar they need to grow.
People also search for: dog pyoderma treatment · erythritol for dogs skin infection · how to treat dog skin problems
Abstract
(SC) belongs to a group of coagulase-positive staphylococci occasionally isolated from the skin lesions of dogs with pyoderma. We recently revealed that erythritol, a sugar alcohol, inhibited the growth of SC strain JCM7470. This study investigated the molecular mechanisms involved in this growth inhibition of JCM7470 by erythritol, and determine whether erythritol inhibits the growth of SC isolated from the skin of dogs with pyoderma. Comprehensive analysis of the gene expression of JCM7470 in the presence of erythritol revealed that erythritol upregulated the expression ofandgenes, both of which encode phosphotransferase system (PTS) glucoside- and glucose-specific permease C, B, and A domains (EIICBA), respectively, associated with sugar uptake. Moreover, erythritol suppressedgrowth of all 27 SC strains isolated from the skin lesions of canine pyoderma, including 13gene-positive and 14gene-negative strains. Finally, the growth inhibition of the SC clinical isolates by erythritol was restored by the addition of glucose. In summary, we revealed that erythritol promotes PTS gene expression and suppresses thegrowth of SC clinical isolates from dogs with pyoderma. Restoration of the erythritol-induced growth inhibition by glucose suggested that glucose starvation may contribute to the growth inhibition of SC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38239752/