Peer-reviewed veterinary case report
Horse showing poor performance and anemia after human erythropoietin
By Piercy, R J et al.·Published in Journal of the American Veterinary Medical Association·1998·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Erythroid hypoplasia and anemia following administration of recombinant human erythropoietin to two horses.
- Species:
- horse
Plain-English summary
A Standardbred gelding and a colt were brought in because they were performing poorly and had anemia. Both horses had received a medication called recombinant human erythropoietin (rhEPO) multiple times over the past few months, which led to low red blood cell production. After stopping the rhEPO and starting treatment with dexamethasone, both horses improved significantly. Five months later, one horse's red blood cell levels had returned to normal, and both were back in training.
People also search for: horse anemia treatment · Standardbred poor performance · rhEPO side effects in horses
Abstract
A Standardbred gelding and a colt were examined because of poor performance and anemia. Each horse had been given recombinant human erythropoietin (rhEPO; 4,000 IU) at least twice within the preceding 2 to 4 months. The horses had an Het of 16 and 24%, serum iron concentrations of 210 and 304 micrograms/dl (reference range, 73 to 140 micrograms/dl), total iron binding capacities of 239 and 321 micrograms/dl (reference range, 266 to 364 micrograms/dl), values for the percentage saturation of transferrin by iron of 87.9 and 94% (reference range, 20 to 52%), and serum ferritin concentrations of 255 and 355 ng/ml (reference range, 43 to 261 ng/ml), respectively. There was no clinical or laboratory evidence of immune-mediated hemolysis or an infectious or inflammatory cause of the anemia. Examination of sternebral marrow biopsy specimens revealed generalized bone marrow hypoplasia; myeloid-to-erythroid ratios were 6.7 and 3.2. Moderate-to-marked erythroid hypoplasia was diagnosed in both horses. Compared with serum from a healthy control horse, serum from the affected horses inhibited rhEPO-induced proliferation of erythroid progenitors in vitro. Results suggested that the horses had developed anti-rhEPO antibodies that cross-reacted with endogenous erythropoietin, thereby inhibiting erythropoiesis. Horses were discharged with instructions that rhEPO administration be discontinued and that dexamethasone be administered. Five months later, both horses were back in training. For 1 horse, Hct had increased to 35%, and the other horse was not available for examination.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/9448829/