Peer-reviewed veterinary case report
Dog with rare multiple myeloma causing severe anemia and spleen tumor
By Romanelli, Pierpaolo et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2022·MYLAV Laboratory, Italy·View original on PubMed →
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Original publication title: Erythrophagocytic multiple myeloma in a dog.
- Species:
- dog
Plain-English summary
A 5-year-old spayed female Golden Retriever was brought to the vet because she had severe anemia (low red blood cells) and low platelet counts, which can lead to bleeding problems. Blood tests showed high protein levels, and a sample taken from her spleen revealed cancerous cells that were eating red blood cells, indicating a rare type of cancer called erythrophagocytic multiple myeloma. Unfortunately, the dog was euthanized due to the severity of her condition, and further tests confirmed the presence of this aggressive cancer.
People also search for: dog anemia symptoms · Golden Retriever cancer treatment · erythrophagocytic multiple myeloma in dogs
Abstract
A 5-y-old spayed female Golden Retriever dog was referred because of severe normocytic normochromic nonregenerative anemia and thrombocytopenia. Serum analysis revealed hyperproteinemia and monoclonal or oligoclonal gammopathy. Fine-needle aspiration of the spleen revealed a highly erythrophagocytic population of neoplastic round cells, morphologically suggestive of plasma cells. After euthanasia, histologic assessment of the spleen and liver revealed an erythrophagocytic round cell tumor. Immunohistochemical analysis of the tumor population was positive for MUM1p and negative for CD3, CD20, and Iba-1, confirming the plasma cell origin of the tumor. Erythrophagocytic multiple myeloma is a very rare neoplastic condition in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35603564/