Peer-reviewed veterinary case report
Follicular cystitis in dogs linked to E. coli infection
By Viitanen, Sanna J et al.·Published in Journal of veterinary internal medicine·2023·Department of Equine and Small Animal Medicine·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Escherichia coli-associated follicular cystitis in dogs: Clinical and pathologic characterization.
- Species:
- dog
Plain-English summary
Eight female dogs, mostly large breeds, were diagnosed with follicular cystitis, which is an uncommon bladder condition often linked to chronic urinary tract infections (UTIs). These dogs had been experiencing symptoms for an average of seven months and had a history of multiple UTIs. Testing revealed that Escherichia coli bacteria were present in the bladder tissue of most dogs, suggesting it may play a role in causing this condition. Treatment focused on managing the underlying infections and inflammation, which is crucial for recovery.
People also search for: dog urinary tract infection treatment · dog bladder inflammation symptoms · why is my dog peeing frequently
Abstract
BACKGROUND: Follicular cystitis is an uncommon inflammatory change in the urinary bladder wall characterized by the formation of tertiary lymphoid structures (TLSs) in the submucosa. OBJECTIVES: To characterize clinical and pathologic features of follicular cystitis in dogs and to explore in situ distribution and possible role of Escherichia coli as an associated cause. ANIMALS: Eight dogs diagnosed with follicular cystitis and 2 control dogs. METHODS: Retrospective descriptive study. Dogs diagnosed with follicular cystitis (macroscopic follicular lesions in the urinary bladder mucosa and histopathologic detection of TLSs in bladder wall biopsies) were identified from medical records. Paraffin embedded bladder wall biopsies were subject to in situ hybridization for E. coli 16SrRNA identification. RESULTS: Follicular cystitis was diagnosed in large breed (median weight 24.9 kg, interquartile range [IQR] 18.8-35.4 kg) female dogs with a history of chronic recurrent urinary tract infections (UTIs; median duration of clinical signs 7 months, IQR 3-17 months; median number of previous UTIs 5, IQR 4-6). Positive E. coli 16SrRNA signal was detected within developing, immature and mature TLSs in 7/8 dogs, through submucosal stroma in 8/8 dogs and within the urothelium in 3/8 dogs. CONCLUSIONS AND CLINICAL IMPORTANCE: Chronic inflammation associated with an intramural E. coli infection in the urinary bladder wall represents a possible triggering factor for the development of follicular cystitis.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37154220/