Peer-reviewed veterinary case report
Establishment of an-based assay using a silkworm infection model for phenotypic evaluation of antimicrobial drug combinations against.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2026
- Authors:
- Yagi, Akiho et al.
- Affiliation:
- Faculty of Pharmaceutical Sciences · Japan
Abstract
exhibits high intrinsic drug resistance, requiring combination therapy. We developed a silkworm () infection model as a whole-organism,-based platform for quantitative, outcome-based evaluations of antimicrobial combinations. The system, examined using clarithromycin-amikacin and imipenem-cefoxitin combinations, showed interaction profiles that were qualitatively consistent with those observed. This rapid, reproducible, and ethical assay enables reliable phenotypic assessments of synergistic or antagonistic effects and may facilitate the evaluation and prioritization of antimicrobial combination regimens in preclinical studies.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/41711408/