Peer-reviewed veterinary case report
How common is Type 2 Von Willebrand disease in German Wirehaired
By Gavazza, Alessandra et al.·Published in Research in veterinary science·2012·Department of Veterinary Clinic, Italy·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Estimated prevalence of canine Type 2 Von Willebrand disease in the Deutsch-Drahthaar (German Wirehaired Pointer) in Europe.
- Species:
- dog
Plain-English summary
A study found that Type 2 Von Willebrand disease (VWD), a serious bleeding disorder, affects a small number of German Wirehaired Pointers in Europe. Out of 1,855 dogs tested, most were clear of the disease-causing mutation, but a few were carriers or affected. The highest rates of the mutation were found in Germany and Sweden. This information is important for breeders and owners, as a DNA test is now available to screen dogs for this condition, helping to prevent the disease in future generations.
People also search for: German Wirehaired Pointer bleeding disorder · Type 2 Von Willebrand disease in dogs · dog DNA test for VWD
Abstract
Type 2 Von Willebrand disease (VWD) is a severe coagulopathy occurring in the Deutsch-Drahthaar dog (or German Wirehaired Pointer, DD/GWP). Recently, a causative recessive mutation has been identified, and a DNA test is now available for individual screening. The genotype distribution (clear, carrier, and affected dogs) was investigated in 1855 DD/GWP dogs using data collected by the DD DNA-VWD-Databank in several European countries. 1704 (91.8%) DD/GWP dogs were genotypically clear of the VWD mutation, 144 (7.8%) were carriers, and seven (0.4%) were affected. The estimated disease allele frequency was highest in Germany and Sweden (almost 5%), and about 1% in Denmark, Finland and Norway. The Hardy-Weinberg equilibrium was tested in the German sample, and showed no evidence of deviation.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22824509/