Peer-reviewed veterinary case report
Estimation of Absolute Bioavailability of the Chemical Substance of the Anti-Smallpox Preparation NIOCH-14 in Mice.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2020
- Authors:
- Mazurkov, O Yu et al.
- Affiliation:
- State Research Center of Virology and Biotechnology "Vector"
- Species:
- rodent
Abstract
We compared absolute bioavailability of the chemical substance of the anti-smallpox preparation NIOCH-14 and chemical compound ST-246 active against orthopoxviruses after oral administration to mice in doses of 10 and 50 μg/g and intravenous administration to mice in a dose of 2 μg/g body weight. The absolute bioavailability of NIOCH-14 is comparable with the absolute bioavailability of ST-246.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33263846/