Peer-reviewed veterinary case report
Estimating heart filling pressure in dogs with pacing-induced heart
By Schober, K E et al.·Published in Journal of veterinary internal medicine·2008·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Estimation of left ventricular filling pressure by Doppler echocardiography in dogs with pacing-induced heart failure.
- Species:
- dog
Plain-English summary
Five male hound dogs with mild congestive heart failure (CHF) were studied to see how well Doppler echocardiography could predict heart pressure changes. The dogs were paced to induce heart failure and then given furosemide, a diuretic, which successfully lowered their left ventricular filling pressure. The study found that the ratio of early transmitral flow velocity to isovolumic relaxation time was the best predictor of heart pressure changes. This information can help veterinarians assess heart function in dogs with CHF and guide treatment decisions.
People also search for: dog heart failure treatment · hound dog heart problems · furosemide for dogs heart disease
Abstract
BACKGROUND: Congestive heart failure (CHF) is a common clinical syndrome characterized by elevated filling pressure. HYPOTHESIS: Doppler echocardiographic (DE) variables of left ventricular (LV) filling can predict a decline of LV end-diastolic pressure (LVEDP) induced by acute preload reduction in dogs with compensated CHF. ANIMALS: Five male hound dogs. METHODS: Dogs previously instrumented with a transvenous cardiac pacemaker and a LV pressure gauge were paced at 160-180 bpm to induce mild CHF characterized by LVEDP > 20 mmHg. LVEDP and 9 DE variables of LV filling derived from diastolic time intervals, transmitral and pulmonary venous flow, and tissue Doppler imaging were measured simultaneously at baseline and 30, 60, 120, and 240 minutes after furosemide (4 mg/kg, IV) or placebo (0.9% saline, IV). Repeated measures analysis of variance and correlation analysis were used to determine the association between the decline of LVEDP after furosemide and DE measures of LV filling pressure (LVFP). RESULTS: Furosemide but not placebo decreased LVEDP (P < .001). The ratio of early transmitral flow velocity to LV isovolumic relaxation time (E : IVRT) predicted LVEDP best (R(2)= .50; P < .001). Correlations were also found between LVEDP and IVRT, E, ratio between E and late diastolic transmitral flow velocity (E : A), and early diastolic velocity of the mitral annulus (Ea). The ratio of E to Ea (E : Ea) was not useful in the prediction of LVEDP in this model. CONCLUSION AND CLINICAL IMPORTANCE: E : IVRT can be used to predict LVFP in dogs with mild left-sided CHF induced by rapid pacing.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18466238/