Peer-reviewed veterinary case report
Estradiol administration mediates the inflammatory response to formalin in female rats.
- Journal:
- Brain research
- Year:
- 2005
- Authors:
- Kuba, Tzipora et al.
- Affiliation:
- Department of Psychology · United States
- Species:
- rodent
Abstract
Female rats demonstrate higher pain sensitivity than do males in various nociceptive assays of inflammation. In the present study, we found that estradiol (20%) replacement in ovariectomized rats attenuated the chronic phase of the formalin response but only at high formalin concentrations thought to rely on peripheral inflammation. An inactive isomer of estradiol, alpha-estradiol, failed to result in the same attenuation (P > 0.05). Our results suggest that estradiol's actions in inflammatory responses are mediated through genomic estrogen receptor-mediated mechanisms.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15893295/