Peer-reviewed veterinary case report
Ethylene glycol poisoning in dogs and early hemodialysis treatment
By Schweighauser, A & Francey, T·Published in Schweizer Archiv fur Tierheilkunde·2016·View original on PubMed →
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Original publication title: Ethylene glycol poisoning in three dogs: Importance of early diagnosis and role of hemodialysis as a treatment option.
- Species:
- dog
Plain-English summary
Three dogs were brought to the vet after they ingested antifreeze, which contains ethylene glycol and can cause serious kidney damage. They showed symptoms like excessive urination, increased thirst, vomiting, and difficulty walking. The veterinarians emphasized the importance of early diagnosis and started treatment within 8 hours of ingestion. They used supportive care along with hemodialysis, a procedure that helps remove toxins from the blood. Fortunately, the dogs received prompt treatment, which improved their chances of recovery.
People also search for: dog antifreeze poisoning symptoms · ethylene glycol treatment for dogs · dog kidney failure recovery
Abstract
Poisoning with ethylene glycol as contained in antifreeze can rapidly lead to irreversible acute renal failure and other organ damage. It carries a grave prognosis unless diagnosed early and adequate treatment is initiated within 8 hours of ingestion. Toxicity of ethylene glycol is related to the production of toxic metabolites by the enzyme alcohol dehydrogenase (ADH), leading to early signs of severe polyuria (PU) and polydipsia (PD), gastritis, ataxia and central nervous depression, followed by progressive dehydration, and ultimately oligoanuric renal failure. In addition to general supportive care, therapeutic interventions must include either antidotes blocking ADH-mediated metabolism or blood purification techniques to remove both the parent compound and the toxic metabolites. The goal of this case report is to describe three cases of acute antifreeze intoxication in dogs, and to discuss treatment options available for this poisoning.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27145686/