Peer-reviewed veterinary case report
Etiology and Pathophysiology of Diabetes Mellitus in Dogs.
- Journal:
- The Veterinary clinics of North America. Small animal practice
- Year:
- 2023
- Authors:
- O'Kell, Allison L & Davison, Lucy J
- Affiliation:
- Department of Small Animal Clinical Sciences · United States
- Species:
- dog
Abstract
Canine diabetes results from a wide spectrum of clinical pathophysiological processes that cause a similar set of clinical signs. Various causes of insulin deficiency and beta cell loss, insulin resistance, or both characterize the disease, with genetics and environment playing a role. Understanding the genetic and molecular causes of beta cell loss will provide future opportunities for precision medicine, both from a therapeutic and preventative perspective. This review presents current knowledge of the etiology and pathophysiology of canine diabetes, including the importance of disease classification. Examples of potential targets for future precision medicine-based approaches to therapy are discussed.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/36854636/