Ets-1 represents a pivotal transcription factor for viral clearance, inflammation, and demyelination in a mouse model of multiple sclerosis.

Abstract

Demyelination of Theiler's murine encephalomyelitis (TME) depends on viral persistence and on the mouse genotype. Ets-1 expression, a transcription factor involved in T cell activation and cytokine expression, was investigated in the spinal cord during TME using RT-qPCR and immunohistochemistry. Resistant C57BL/6 mice lacking virus persistence and demyelination demonstrated a stronger upregulation of Ets-1 mRNA transcripts in the early phase of TME compared to susceptible SJL/J mice probably linked to viral clearance. Though strong Ets-1 expression in resident glial cells such as astrocytes might inhibit lesion development, delayed Ets-1 activation in inflammatory cells seemed to promote demyelination in the late phase of TME in SJL/J mice.