Peer-reviewed veterinary case report
Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus.
- Journal:
- Brain research
- Year:
- 2004
- Authors:
- Irie, Yoshifumi et al.
- Affiliation:
- Department of Oriental Medicine · Japan
- Species:
- rodent
Abstract
Here we show that eugenol has an antidepressant-like activity comparable to that of imipramine using a forced swim test and a tail suspension test in mice. Furthermore, we show that both eugenol and imipramine induce brain-derived neurotrophic factor (BDNF) in the hippocampus with and without induction of metallothionein-III (MT-III), respectively. It may be possible that MT-III expression is involved in the exhibition of antidepressant-like activity of eugenol, not of imipramine.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15157811/