Evaluating the Efficacy of Ozone Therapy and Low-Level Laser Therapy in Treating Premalignant and Malignant Lesions: A Systematic Review.

Abstract

<h4>Introduction</h4>Premalignant lesions and conditions are comparably frequent, arising in less than 3% of the general public and a possible objective for cancer prevention. In a workshop conducted by WHO in 2005, the topic of discussion was "Oral lesion with a predisposition to malignant transformation"; thus, they proposed the term "Potentially Malignant Disorders [OPMDs]". Therefore, patients evaluated with OPMDs may have an inclined vulnerability to develop lesion anywhere in their mouth during their lifetime. There are various treatment modalities in treating OPMDs, among which the looming and imminent treatment modality is "Laser therapy" using "Low level laser therapy [LLLT] and Ozone therapy".<h4>Aims and objectives</h4>Evaluating the efficaciousness of LLLT and ozone therapy in treating OPMDs.<h4>Methodology</h4>This systematic review was performed using PRISMA guidelines. Systematic search of the literature was done with specific MESH keywords.<h4>Results</h4>Based on the preformatted criteria, 12 articles were scrutinized and critically analyzed in the PICO format. Therefore, LLLT and ozone therapy have proven to be beneficial in treating premalignant lesions.<h4>Conclusion</h4>Various treatment modalities exist in treating OPMDs; one of the less ventured and yet promising modalities is laser irradiation using LLLT and ozone therapy.