Peer-reviewed veterinary case report
Microdosing 1cp-LSD helped reduce anxiety in a senior dog
By Hernández-Álvarez, Elisa et al.·Published in Veterinary medicine and science·2025·Faculty of Veterinary, Spain·View original on PubMed →
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Original publication title: Evaluating the Potential of Microdosing 1cp-LSD for the Treatment of Canine Anxiety: A One-Month Case Study.
- Species:
- dog
Plain-English summary
A 13-year-old female dog with severe separation anxiety was treated with a microdose of a substance called 1cp-LSD every three days for a month. After the treatment, her anxiety levels significantly decreased, leading to less destructive behavior and shorter periods of barking when left alone. The improvement in her anxiety was still noticeable a month later, although she did bark more frequently. While these results are promising, more research is needed to confirm the effectiveness of this treatment and rule out other factors that might have influenced her behavior.
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Abstract
This pilot study explored the potential of microdosing 1-cyclopropionyl-d-lysergic acid diethylamide (1cp-LSD) to treat canine anxiety. A single-case study was conducted on a 13-year-old female dog with severe separation anxiety, who was treated with 5 µg of 1cp-LSD every 3 days for a month. Anxiety was assessed before, after, and 1 month following treatment using a validated questionnaire. The owner's attachment style was assessed using a validated scale. The dog's anxiety score significantly decreased from 29 (severe) to 14 (moderate) after treatment. A reduction in anxiety levels was observed, characterized by decreased destructive behaviour and shorter durations of vocalization. This improvement was sustained 1 month following treatment, although vocalization frequency increased. These findings suggest potential therapeutic efficacy of microdosing 1cp-LSD in managing canine anxiety; however, the absence of a control group makes it difficult to determine whether the observed effects are due to 1cp-LSD, owner bias, or natural variability in the dog's behaviour. Additional studies with blinded protocols and larger sample sizes are necessary to validate these findings and further explore the impact of owner attachment on canine anxiety.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40638522/