Peer-reviewed veterinary case report
Using PhasixST Mesh for Laparoscopic Repair of Large Hiatal Hernias
By Kourtidis L et al.·2025·1st Surgical Department·View original on Europe PMC →
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Original publication title: Evaluating the Role of PhasixST™ Mesh in Laparoscopic Repair of Large Hiatal Hernias: Surgical Technique and Comprehensive Review of the Literature.
Plain-English summary
Recent research has looked at using a special type of mesh called PhasixST™ for fixing large hiatal hernias, which are bulges in the diaphragm that can cause problems like heartburn or difficulty swallowing. This mesh is made from a material that slowly breaks down over 12 to 18 months, allowing the body to heal and integrate the mesh into its own tissue. Studies show that using this mesh results in very few cases of hernias coming back and no reported complications related to the mesh itself. The surgery involves carefully placing the mesh to ensure it stays in the right position and helps support the area properly. Overall, the use of PhasixST™ mesh appears to be effective for repairing hiatal hernias with a low risk of complications.
Abstract
The application of bioabsorbable PhasixST™ mesh in the laparoscopic repair of large hiatal hernias has emerged as a promising strategy to address the limitations associated with permanent synthetic meshes, particularly the risk of mesh-related complications and long-term morbidity. Recent studies have demonstrated that PhasixST™ mesh, composed of poly-4-hydroxybutyrate (P4HB), is slowly absorbed over 12 to 18 months, providing a scaffold that supports native tissue integration and healing during the critical postoperative period. This gradual absorption profile may confer an advantage over more rapidly degrading bioabsorbable meshes, as it allows for more robust tissue ingrowth and potentially enhances the durability of hiatal reinforcement. The association between P4HB mesh use and low recurrence rates has been highlighted, with an average of 2.82 hernia recurrences per 100 patients within one year, and no mesh-related complications in the current literature. The surgical technique for PhasixST™ mesh placement involves meticulous crural reinforcement, with careful attention to mesh orientation and fixation to minimize the risk of migration or erosion. The primary objective is to restore the anatomical integrity of the hiatus, reduce the size of the defect, and prevent recurrence, while minimizing perioperative morbidity.
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Search related cases →Original publication on Europe PMC: https://europepmc.org/article/MED/41375619