Peer-reviewed veterinary case report
DGGR lipase levels in cats with and without kidney disease
By Bua, Anne-Sophie et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2020·Department of Clinical Sciences·View original on PubMed →
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Original publication title: Evaluation of 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6'-methylresorufin) ester lipase concentrations in cats with kidney disease and with normal SNAP fPL.
- Species:
- cat
Plain-English summary
A group of cats with kidney disease had their blood tested for a specific enzyme (DGGR lipase) to see if it could help diagnose pancreatitis. The results showed that cats with kidney disease had slightly higher levels of this enzyme compared to healthy cats, but the difference was small and not likely to affect treatment decisions. Most of the cats' enzyme levels were still within the normal range. This suggests that while kidney disease can influence DGGR lipase levels, it may not be a reliable indicator for diagnosing pancreatitis in cats.
People also search for: cat kidney disease symptoms · pancreatitis in cats · DGGR lipase test for cats
Abstract
Measuring 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6'-methylresorufin) ester (DGGR) lipase activity is a cost-effective test for diagnosing pancreatitis compared to the feline pancreas-specific lipase (Spec fPL) test. However, little is known about the influence of renal insufficiency on DGGR lipase in cats. This study evaluated the influence of renal function on serum DGGR lipase in the cat. Serum samples from 49 cats with normal pancreas-specific lipase immunoreactivity were analyzed for DGGR lipase activity and serum creatinine. Median serum DGGR lipase activity for cats with kidney disease (KD+) was 22 IU/L (range: 9 to 29 IU/L), whereas for cats without kidney disease (KD-) and healthy cats, the medians were 16 IU/L (range: 6 to 32 IUI/L), and 15 IU/L (range: 9 to 23 IU/L), respectively. The KD+ group had significantly higher DGGR lipase concentrations compared to the healthy group (= 0.030), but most results were within the reference range. There was a weak positive correlation between creatinine and DGGR lipase values (= 19.6%;= 0.0014) and no significant correlation between symmetric dimethylarginine (SDMA) and DGGR lipase. Key clinical message: Although cats with kidney disease had significantly higher serum DGGR lipase concentrations than the healthy controls, the difference was small and does not appear to be clinically relevant.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32655158/