Peer-reviewed veterinary case report
Hydrogel treatment helps heal dog bone defects faster
By Ibrahim, Ahmed et al.·Published in Journal of materials chemistry. B·2025·Veterinary Teaching Hospital·View original on PubMed →
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Original publication title: Evaluation of a chitosan/polyvinyl alcohol hydrogel loaded with graphene oxide and nano TiOfor bone defect reconstruction in a dog model.
- Species:
- dog
Plain-English summary
A group of dogs with bone defects in their radius bones underwent surgery to test a new hydrogel treatment made from chitosan, polyvinyl alcohol, graphene oxide, and nano titanium oxide. After surgery, the dogs that received the hydrogel showed no limping by three weeks, while those that did not receive the treatment still had mild limping. The treated dogs also had significantly smaller bone defects and better bone density on X-rays compared to the untreated dogs. This suggests that the hydrogel could be an effective option for helping dogs heal from bone injuries.
People also search for: dog bone injury treatment · dog limping after surgery · hydrogel for dog bone healing
Abstract
This study evaluated the application of chitosan/polyvinyl alcohol/graphene oxide/nano titanium oxide (CS/PVA/GO/nano TiO) hydrogels for bone defect reconstruction in dogs. Dogs were subjected to mid-diaphyseal circular bone defects (0.8 cm) in the radius bones. Bone defects were implanted with the hydrogel in the treated group (= 9), while the control group were subjected to spontaneous healing (= 9). Dogs were subjected to clinical, radiographic, and scanning electron microscopy (SEM) evaluations at 15-, 30-, and 45-days post-surgery. Dogs in the treated group recorded no lameness by the end of the third week post-surgery, while dogs in the untreated group still exhibited lameness of grade 1. There was a significant decrease (< 0.05) in the cortical defect (mm) of the treated group (5.46 ± 0.17 and 1.45 ± 0.13) compared with the control group (7.57 ± 0.05 and 7.59 ± 0.06) at 30- and 45-days post-surgery, respectively. The depth of the bone defects (mm) decreased significantly (< 0.05) in the treated group (2.26 ± 0.12 and 0.008 ± 0.002) compared with the untreated group (4.05 ± 0.05 and 2.16 ± 0.07) at 30- and 45-days post-surgery, respectively. Throughout the period of study, there was a significant increase (< 0.05) in the radiographic density of the bone defects (px) in the treated group (474 ± 17.88) compared with that in the control group (619.6 ± 6.85). SEM results revealed complete closure of the bone defects in the treated group. Thus, implantation of bone defects with the CS/PVA/GO/nano TiOhydrogel represents a promising bone graft substitute for accelerating bone healing.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39957679/