Peer-reviewed veterinary case report
Testing a new osteoarthritis marker in dogs with cruciate ligament
By Hayashi, Kei et al.·Published in Veterinary surgery : VS·2009·Department of Surgical & Radiological Sciences, United States·View original on PubMed →
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Original publication title: Evaluation of a collagenase generated osteoarthritis biomarker in naturally occurring canine cruciate disease.
- Species:
- dog
Plain-English summary
A group of dogs with cranial cruciate ligament (CCL) ruptures was tested for a new biomarker that was thought to help detect osteoarthritis (OA) related to this injury. However, the study found that this biomarker did not show any significant differences between dogs with CCL ruptures and healthy dogs. While the dogs with CCL injuries showed more severe symptoms like limping and joint swelling, the biomarker did not correlate with the severity of their condition. This means that the biomarker is not helpful for diagnosing CCL ruptures in dogs.
People also search for: dog limping CCL injury · osteoarthritis biomarker dogs · treatment for dog knee problems
Abstract
OBJECTIVE: To determine the clinical value of a novel osteoarthritis (OA) biomarker in detecting canine cruciate disease. STUDY DESIGN: Cross sectional clinical study. ANIMALS: Dogs (n=22) with cranial cruciate ligament (CCL) rupture and 12 control dogs. METHODS: Concentrations of collagenase-generated cleavage epitope of type II collagen (Col2-3/4C(long mono), or C2C) in serum, urine, and joint fluid were compared between a group of dogs with CCL rupture and a control group. Correlation of C2C concentrations to the clinical stage of stifle OA was also evaluated. RESULTS: There were no significant differences in C2C concentrations in serum, urine, and joint fluid between groups (P>.05). Subjective scores of lameness, joint effusion, osteophytosis were significantly more severe in the CCL rupture group compared with the control group (P<.05). There was no significant correlation of C2C concentrations with clinical stage of stifle OA (P>.05). CONCLUSION: This OA biomarker did not detect pathology associated with CCL rupture. Our results suggest that collagenase-specific degradation of type II collagen in articular cartilage may not be involved in the early stage of naturally occurring canine cruciate disease, and that pathology associated with naturally occurring CCL rupture is different from that of experimental OA model. CLINICAL RELEVANCE: C2C is not clinically useful in detecting CCL rupture in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19152626/