Peer-reviewed veterinary case report
Evaluation of a neurodevelopmental model of schizophrenia--early postnatal PCP treatment in attentional set-shifting.
- Journal:
- Behavioural brain research
- Year:
- 2008
- Authors:
- Broberg, Brian Villumsen et al.
- Affiliation:
- Department of Psychopharmacology
- Species:
- rodent
Abstract
Phencyclidine (PCP) was administered to male and female Lister hooded rats on postnatal days (PND) 7, 9 and 11. All PCP animals tested in adulthood (PND 53-93) showed deficits in cognitive flexibility, specifically in their ability to shift attentional set, compared to controls. This novel finding is reminiscent of the impairment observed in schizophrenia patients, and supports the validity of the early postnatal PCP regimen as a disease-like model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18367258/