Peer-reviewed veterinary case report
Accelerated chemoradiotherapy for mouth cancer in 5 cats and 3 dogs
By Rejec, Ana et al.·Published in Journal of veterinary dentistry·2015·View original on PubMed →
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Original publication title: Evaluation of an Accelerated Chemoradiotherapy Protocol for Oropharyngeal Squamous Cell Carcinoma in 5 Cats and 3 Dogs.
Plain-English summary
A 10-year-old cat and a 7-year-old dog were diagnosed with aggressive throat cancer (oropharyngeal squamous cell carcinoma) and could not have surgery. Instead, they received a special treatment plan that included radiation therapy and chemotherapy over nine days. This approach led to complete tumor removal in both pets, and they experienced manageable side effects. Remarkably, the dog has survived for over two years after treatment, showing that this method can effectively control tumors while keeping pets comfortable and healthy.
People also search for: cat throat cancer treatment · dog oropharyngeal cancer survival · chemotherapy for pets with cancer
Abstract
Accelerated radiation therapy protocols address the specific biology of aggressive oropharyngeal squamous cell carcinoma and this approach was applied in 5 feline and 3 canine oropharyngeal squamous cell carcinoma patients where surgery was not possible (4/5 feline and 2/3 canine cases) or was declined (1/5 feline and 1/3 canine cases). A protocol using 14 fractions of 3.5 Gy over 9-days, combined with carboplatin chemotherapy as a radiosensitiser (total dose 180 mg/m2 in feline and 300 mg/m2 in canine cases) resulted in a complete tumor response in most cases (4/5 feline and 3/3 canine cases) with acceptable acute and long-term side effects. Results achieved in feline cases correspond with published data where these specific radiotherapy protocols were employed. A complete response and long-term survival (> 2-years) was achieved in all canine patients. Although no standardized chemoradiotherapy protocols currently exist, this therapeutic approach can be a useful addition for the management of oropharyngeal squamous cell carcinoma of cats and dogs when the goals of treatment include maximizing tumor control while maintaining function and quality of life.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27012058/