Peer-reviewed veterinary case report
Blood test for prostate enlargement in middle-aged male dogs
By Pinheiro, Dora et al.·Published in BMC veterinary research·2017·University of Trá·View original on PubMed →
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Original publication title: Evaluation of biomarker canine-prostate specific arginine esterase (CPSE) for the diagnosis of benign prostatic hyperplasia.
- Species:
- dog
Plain-English summary
A 5-year-old intact male dog was evaluated for signs of benign prostatic hyperplasia (BPH), a common condition in older male dogs that can lead to prostate enlargement. Researchers found that measuring a specific blood marker, canine prostate-specific arginine esterase (CPSE), was effective in diagnosing BPH. The study showed that dogs with BPH had significantly higher CPSE levels compared to healthy controls, and this test correlated well with other diagnostic methods. This means that CPSE testing could be a reliable option for vets when diagnosing prostate issues in middle-aged male dogs.
People also search for: dog prostate problems symptoms · benign prostatic hyperplasia treatment in dogs · CPSE test for dog prostate health
Abstract
BACKGROUND: Benign prostatic hyperplasia (BPH) is the most common canine prostatic disorder. Although most or even all intact male dogs may develop BPH by 5-8 years of age, many show no clinical signs. Taking into account the non-specific character of clinical and ultrasonographic findings, a new diagnostic approach has recently been proposed based on the augmentation of blood canine prostate-specific arginine esterase (CPSE) in hyperplasic dogs. The aim of the present study was to verify CPSE levels in negative controls and hyperplasic dogs, considering cytological findings as the reference method and taking into account the fact that controls were middle-aged intact dogs (median of 5.0 years), contrarily to previous studies carried out with very young control dogs. RESULTS: Significant differences of median CPSE levels were found between controls and hyperplasic dogs (29.1 versus 160.7 ng/mL, respectively); and significant positive correlations were found between median CPSE levels and age or prostatic volume (r = 0.549 and 0.448, respectively; p < 0.001). Sensitivity, specificity, positive and negative likelihood ratios put into evidence the good performance of the test. The agreement between methods was found to be very high, notably between CPSE levels and cytological results (Cohen's kappa coefficients above 0.8). CONCLUSIONS: Considering the results all together, measurement of CPSE is confirmed as a useful and accurate method and should be considered as an alternative or complementary tool to conventional methods for the diagnosis of BPH in middle-aged dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28335775/